Application Information

This drug has been submitted to the FDA under the reference 020298/001.

Names and composition

"ALOPRIM" is the commercial name of a drug composed of ALLOPURINOL SODIUM.


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Answered questions

What is allopurinol medication?
medication Asked by Ana Fernberg 2 years ago.

GENERIC NAME: allopurinol BRAND NAME: Zyloprim, Aloprim DRUG CLASS AND MECHANISM: Allopurinol is used for treating gout caused by excessive levels of uric acid in the blood (hyperuricemia). Uric acid is a by product from the breakdown of certain proteins (purines) in the body. Hyperuricemia occurs when the body produces more uric acid than it can eliminate. The uric acid forms crystals in joints (gouty arthritis) and tissues, causing inflammation and pain. Elevated blood uric acid levels also can cause kidney disease and stones. Allopurinol prevents the production of uric acid by blocking the activity of the enzyme that converts purines to uric acid. Uric acid levels usually begin to fall within 2-3 days of starting treatment and return to their original levels within 7-10 days after allopurinol is stopped. It may take several months of therapy before attacks of gout are controlled. The FDA approved allopurinol prior to 1982. PRESCRIPTION: Yes GENERIC AVAILABLE: Yes PREPARATIONS: Tablets: 100, 300 mg; Powder for injection: 500 mg STORAGE: Tablets should be stored at room temperature between 15 to 25 C (59-77 F) and in a moisture proof, light- resistant container. Powder should be stored between 20 and 25 C (68-77 F) and not refrigerated. PRESCRIBED FOR: Allopurinol is used for treating acute attacks of gout, erosive destructive gouty joint disease, uric acid deposits in tissues (tophi), gouty kidney disease, and uric acid stones. Allopurinol also is used to prevent elevation of blood uric acid in patients undergoing chemotherapy for the treatment of certain cancers and in patients with recurrent calcium kidney stones and elevated uric acid levels. DOSING: The dose range of allopurinol is 100-800 mg day. It should be taken with food to avoid irritation of the stomach. In order to avoid formation of kidney stones, patients should drink plenty of fluids while taking allopurinol. DRUG INTERACTIONS: Allopurinol increases blood levels of oral mercaptopurine (Purinethol) and azathioprine (Imuran) by reducing their breakdown in the body. Therefore, the dose of mercaptopurine and azathioprine should be reduced in order to avoid toxicity. There is an increased risk of skin rash in patients taking allopurinol in combination with penicillins. PREGNANCY: There are no adequate studies of allopurinol in pregnant women. NURSING MOTHERS: Allopurinol is excreted in breast milk. To avoid adverse effects in the infant, nursing mothers taking allopurinol should consider not breastfeeding. SIDE EFFECTS: Common reactions include diarrhea, nausea, rash and itching, and drowsiness. The most frequent side effect to allopurinol is skin rash. Allopurinol should be discontinued immediately at the first appearance of rash, painful urination, blood in the urine, eye irritation, or swelling of the mouth or lips, because these can be a signs of an impending severe allergic reaction that can be fatal. Allopurinol should be avoided by patients with a prior severe reaction to the drug. Allopurinol can cause a flare-up of gouty arthritis during initial therapy. Therefore, colchicine often is used simultaneously to prevent these flares. Rarely, allopurinol can cause nerve, kidney, and bone marrow damage. Allopurinol can cause a serious allergic liver toxicity that can be fatal. Appetite loss and itching can be signs of liver toxicity. The risk of this reaction increases in patients with kidney impairment. Patients with kidney impairment should receive lower doses of allopurinol. Answered by Kaye Gowan 2 years ago.

The problem with allopurinol medication is that their designed on the basis of “interruption” mechanism. Xanthine oxidase inhibitors disrupt the purine – uric acid cycle by suppressing the enzyme that helps to break down purine to uric acid. Look, God created xanthine oxidase to help us dispose the excess purine in the body. The degradation of purine happens in the liver, and the end product which is uric acid is released back into the bloodstream to be sent to the kidneys for disposal. Blocking this cycle with allopurinol causes the built up of purine in the liver which leads to all sorts of side effects. Answered by Leota Stevenson 2 years ago.

It reduces uric acid production and is used to Prevent (not treat) gout. In fact it will make acutr gout worse. It needs to be started when the patient is free from acute gout, started at a low dose (50mg) and increased slowly. Answered by Vernita Maez 2 years ago.

it blocks the production of uric acid which precipitates in the joints as crystals, which are needle like and cause a lot of pain and swelling. This is known as gout. Answered by Lorna Budak 2 years ago.

neutralizes uric acid in the system....treats gout. Answered by Wen Hoffhines 2 years ago.

No it doesnt to my knowledge. I am on allopurinol, coreg, spironolactone, diovan, and several others with no side effects! Answered by Jeffery Fahnestock 2 years ago.


Side efects of cyclosporine?
Asked by Jona Kilcoyne 2 years ago.

Cyclosporine is a very strong medicine. It may cause side effects that could be very serious, such as high blood pressure and kidney and liver problems. It may also reduce the body's ability to fight infections. You and your doctor should talk about the good this medicine will do as well as the risks of using it. Notify your doctor immediately if you develop fever or chills, a sore throat, unusual bleeding or bruising, mouth sores, abdominal pain, pale stools, or darkened urine. These symptoms could be early signs of dangerous side effects. If you experience any of the following serious side effects, stop taking cyclosporine and seek emergency medical attention or contact your doctor immediately: an allergic reaction (difficulty breathing; closing of your throat; swelling of your lips, tongue, or face; or hives); unusual tiredness or weakness; cough or hoarseness, fever, or chills; painful or difficult urination; severe nausea, vomiting, or diarrhea; unusual bleeding or bruising; seizures; or a sudden unusual feeling of discomfort or illness. Other, less serious side effects may also occur. Continue to take cyclosporine and notify your doctor if you experience tremor (shaking); increased bodily hair growth; gum problems; high blood pressure; numbness or tingling; or decreased appetite. Immunosuppressant drugs such as cyclosporine increase your risk of certain types of cancer, such as lymphomas or skin cancer. Ask you doctor about the risks and benefits of cyclosporine in your treatment. Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome. (back to top) What other drugs will affect cyclosporine? There are many drug/drug interactions with cyclosporine and you should tell your doctor of any drugs you are on and any new drugs, including herbal products, you start. The interactions could alter cyclosporine levels causing a decrease in effectiveness or an increase in side effects. The side effects or effectiveness of the other drugs may also be altered. The following are some examples of medicatoins that may result in a drug/drug interaction when taken with cyclosporine: trimethoprim with sulfamethoxazole (Bactrim, Septra, Sulfatrim, others), gentamicin (Garamycin, others), and vancomycin (Vancocin); ibuprofen (Advil, Motrin, Nuprin, others), naproxen (Naprosyn, Anaprox, Aleve, others), diclofenac (Voltaren, Cataflam), etodolac (Lodine), flurbiprofen (Ansaid), fenoprofen (Nalfon), indomethacin (Indocin), ketorolac (Toradol), ketoprofen (Orudis KT, Orudis, Oruvail), nabumetone (Relafen), oxaprozin (Daypro), piroxicam (Feldene), sulindac (Clinoril), and tolmetin (Tolectin); amphotericin B (Fungizone) and ketoconazole (Nizoral); tacrolimus (Prograf); melphalan (Alkeran); cimetidine (Tagamet, Tagamet HB) and ranitidine (Zantac, Zantac 75); diltiazem (Cardizem, Dilacor XR, Tiazac), nicardipine (Cardene), amiodarone (Cordarone, Pacerone) and verapamil (Calan, Verelan); ketoconazole (Nizoral), itraconazole (Sporanox), and fluconazole (Diflucan); danazol (Danocrine) and methylprednisolone (Medrol, others); erythromycin (Ery-Tab, E-Mycin, E.E.S., P.C.E., others), clarithromycin (Biaxin); bromocriptine (Parlodel); colchicine and allopurinol (Aloprim, Lopurin, Zyloprim); indinavir (Crixivan), nelfinavir (Viracept), ritonavir (Norvir), lopinavir-ritonavir(Kaletra) and saquinavir (Fortovase, Invirase); metoclopramide (Reglan); prednisolone (Prelone, Pediapred, others); digoxin (Lanoxin, Lanoxicaps); lovastatin (Mevacor), fluvastatin (Lescol), pravastatin (Pravachol), simvastatin (Zocor), or atorvastatin (Lipitor); PUVA or UVB therapy; and potassium-sparing diuretics (water pills) such as amiloride (Midamor), spironolactone (Aldactone, Spironol), or triamterene (Dyrenium); and any type of vaccination. Answered by Carie Moers 2 years ago.

Hi -- "It may cause side effects that could be very serious, such as high blood pressure and kidney and liver problems. It may also reduce the body's ability to fight infections. " Answered by Sol Westendorf 2 years ago.

Gout / Alcohol?
my brother can't drink alcohol anymore because he gets the gout real bad in his right foot. He only has one kidney and he's 42. Will this be permanent, because if so, I won't drink around him anymore ??? Asked by Starla Sloma 2 years ago.

Gout is a condition where uric acid crystals build up in the body. This can happen in the area of the big toe and cause a lot of pain. Our foods contain purines; some foods are higher in this than others. The doctor may place you on a lower purine diet (of which they will usually provide you a list of foods to avoid. There is also medications that can lower the uric acid in the blood Here an alternative way to cure gout? Answered by Deeann Araujo 2 years ago.

Yes, its undoubtedly permanent as he is avoiding a gout trigger. I also avoid alcohol for this reason but I don't mind others drinking around me. He may feel the same way. Take care. The link below contains detailed information on gout. Answered by Charleen Xang 2 years ago.

Yes, it's permanent. However there is medications to help allievate the pain and to make the onset of Gout less prominant and less destructive. My brother gets Gout in his right foot all the time. He can't eat a lot of beef or drink either. Answered by Roxanna Maysonet 2 years ago.

Gout is caused by a build up of uric acid, the end product of purine metabolism in your body. Beer is high in malt and will increase the amount of uric acid. Red wine is okay to drink with gout. You should stay away from all other liquors, though. Answered by Kala Maciej 2 years ago.

gout alcohol Answered by Deetta Woolford 2 years ago.

Gout is heavily affected by what you eat and/or drink. If he is experiencing this now, then it will probably affect him for the rest of his life to varying extents. Answered by Lavera Schuber 2 years ago.


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