AGENERASE Ressources

Application Information

This drug has been submitted to the FDA under the reference 021007/001.

Names and composition

"AGENERASE" is the commercial name of a drug composed of AMPRENAVIR.

Answered questions

AGENERASE oral solution contains 1.5% amprenavir. A pharmacist wished to change the drug concentration to 5 mg?
AGENERASE oral solution contains 1.5% amprenavir. A pharmacist wished to change the drug concentration to 5 mg/ mL by using a diluent of polyethylene glycols. How many milliliters of the oral solution and how many milliliters of the diluent should be used to prepare 8 fluid- ounces of the mixture? Asked by Jazmine Agent 3 months ago.

Its very important that when you quote a concentration in percentage, you state whether its mass/volume (m/v %) or volume/volume (v/v %). In your case, 1.5 % could either mean that there is 1.5 g of amprenavir per 100 mL of solution (1.5 % m/v) or it could mean that there is 1.5 mL of amprenavir per 100 mL of solution (1.5 % v/v). Since amprenavir is a solid, the concentration will be m/v but something for you to remember in the future. Always get your units correct :-). For your calculation, we know that we have 1.5 g per 100 mL (which is 15 mg/mL - I converted the grams to mg and divided by 100 to get the answer to per 1 mL) of solution. We want to convert that to 5 mg/mL. We also know that we need 236 mL (8 ounces) of the new solution. So we use the following equation: M1V1 = M2V2 where M1 is the initial concentration, in this case 15 mg/mL V1 is the volume we are trying to find. How much should we remove from the initial solution. M2 is the new concentration, in this case 5 mg/mL V2 is the new volume that we need, in this case 236 mL Now we solve for V1: V1 = (M2 x V2) / M1 = (5 mg/mL x 236 mL) / 15 mg/mL = 78.6 mL We now know that we need 78.6 mL of the initial solution. We also know that we need a final volume of 236 mL. So in order to calculate the amount of diluent needed we just subtract the volumes: vol of diluent = 236 mL - 78.6 mL = 157.4 mL Answered by Kathyrn Cardinali 3 months ago.


Pharmacy...Instructions on label?
Rx: Agenerase 17mg/kg IV tid. (3x daily)onhand Agenerase 15mg/ml Patient is 14y/o and 97lbs.Does___________mgWhich is ___?____Ml.Instructions on label should read????:: --------------------------------------…I tried the problem.97lbs=44.0kg.17mg=1kg so 748mg=44kg. 748*tid=2,244 mg/day. How the... Asked by Stacia Vielhauer 3 months ago.

Rx: Agenerase 17mg/kg IV tid. (3x daily) onhand Agenerase 15mg/ml Patient is 14y/o and 97lbs. Does___________mg Which is ___?____Ml. Instructions on label should read????:: --------------------------------------... I tried the problem. 97lbs=44.0kg. 17mg=1kg so 748mg=44kg. 748*tid=2,244 mg/day. How the HECK do i convert that into 15mg/ml?? So i got 750mg/50ml? Right. So i give Instructions on label shuold read????.. 750mg iv tid. or 250mg iv tid? hmmt. Answered by Kirstin Shortes 3 months ago.

convert pt weight to kg: 97 lbs * kg/2.2 lbs = 44.1 kg calculate dose to be given TID: 17 mg/kg * 44.1 kg = 749.5 mg you have Agenerase 15 mg/mL on hand. use that to convert mg to mL: 749.5 mg * mL/15 mg = 49.97 mL for the label instructions, i would say "50 mL IV TID" i would put the label instructions in mL instead of mg because the medication is available as a solution and the person administering the medication just wants to know what volume to give. Answered by Alessandra Dirollo 3 months ago.

It tells you that in the problem -- "Agenerase 15mg/1 ml onhand" I'll check you. Actually when I did it your way I got different answers than you -- 97 lbs/2.2kg = 44.1 kg (44.09) 44.1kg x 17mg/1kg dose (single) = 749.7 (almost 750, not 748) 749.7x3 = 2249.1mg per DAY 2249.1mg (1ml/15mg) = 149.94 ml per DAY 149.94ml daily/3 doses = 49.98, or 50ml/dose. Rounding will mess you up every time. Answered by Veronika Blois 3 months ago.


This problem makes no sense!?
Rx: Agenerase 17mg/kg IV tid. (3x daily)onhand Agenerase 15mg/ml Patient is 14y/o and 97lbs.Does___________mgWhich is ___?____Ml.----------------------------------------------------I tried the problem.97lbs=44.0kg.17mg=1kg so 748mg=44kg. 748*tid=2,244 mg/day. How the HECK do i convert that into... Asked by Katrina Whaltey 3 months ago.

Rx: Agenerase 17mg/kg IV tid. (3x daily) onhand Agenerase 15mg/ml Patient is 14y/o and 97lbs. Does___________mg Which is ___?____Ml. --------------------------------------... I tried the problem. 97lbs=44.0kg. 17mg=1kg so 748mg=44kg. 748*tid=2,244 mg/day. How the HECK do i convert that into 15mg/ml?? I don't get this problem at all.. And i tried. Answered by Hilario Dang 3 months ago.

OK you did the first part right but you didn't go far enough. One dose is 748mg and you have on hand Agenerase 15mg/ml.You would divide 748 by 15 giving you 49.9(round off to 50).So you would give 50mls for one dose. Answered by Akilah Esquilin 3 months ago.


Can a woman take birth control pills with diet pills and still have the pill be effective?
I am currently on loestrin24e and was wondering is there any research proving that the pill will not be effective if the person takes the pill also? Asked by Kimberli Salina 3 months ago.

The birth control pill consists of hormones which essentially make your body think it is pregnant. Your ovaries will then not release an egg each month, meaning that sperm would have nothing to fertilize. Advantages- very effective when taken properly, can lessen PMS symptoms, lighten "period" bleedings Disadvantages- must remember to take a pill every day, at around the same time. some people experience other side effects. After you stop taking the pill, the extra hormones go away and you can become pregnant again. Your period does not go away completely, but it is more correctly called a "withdrawal bleed," since it is not a true period and is just a break in the hormone dose to allow your body to continue to regulate itself. The pill AND a condom is one of the most effective methods of preventing pregnancy! Perfect use of both methods is over 99% effective. Answered by Augustine Fedder 3 months ago.


Question for someone who knows about birth control?
Yes, the pill is all I count on, since it is 99% effective.I'm 22, living with my bf, and we have sex day and night, so I don't worry about if I'm ovulating since again, I count on the pill.If I am pregnant, I don't even know what I'll do, since I know I don't want to have kids yet, and... Asked by Eddie Grillo 3 months ago.

For the past couple of days, I have been spotting slightly (pink when I wipe). My breasts have been a bit more tender than normal. They're large, and often are, anyway, but like I said, a bit more than normal. Other pregnancy symptoms don't count mostly, since they're typical of me, anyway. I pee a lot, sleep a lot, etc. Because of the spotting, my bf worried a bit I may be pregnant, which I didn't even think of, since I'm always careful with my birth control. I'm on the pill, Lo Ovral. To see if I did anything wrong, I researched a bit and found this: Answered by Leonor Dattilo 3 months ago.

Some drugs can make Lo Ovral less effective, which may result in pregnancy. Before using Lo Ovral, tell your doctor if you are using any of the following drugs: * acetaminophen (Tylenol) or ascorbic acid (vitamin C); * phenylbutazone (Azolid, Butazolidin); * modafinil (Provigil); * dexamethasone (Decadron, Hexadrol); * an antibiotic; * seizure medicines such as phenytoin (Dilantin), carbamazepine (Tegretol), oxcarbazepine (Trileptal), topiramate (Topamax), and others; * a barbiturate such as amobarbital (Amytal), butabarbital (Butisol), mephobarbital (Mebaral), secobarbital (Seconal), or phenobarbital (Luminal, Solfoton); or * HIV medicines such as amprenavir (Agenerase), atazanavir (Reyataz), indinavir (Crixivan), saquinavir (Invirase), fosamprenavir (Lexiva), ritonavir (Norvir), and others. Answered by Marylin Putcha 3 months ago.

I knew about the prescription stuff, but what I'm worried about is the tylenol (I take it usually for headaches and neck-aches) and the Vitamin C (which I take 1000 mg a day to boost my immune system). Does anyone know how much less effective these can make my birth control? I'm concerned, because I really don't want to be pregnant right now. And yes, I know I can take a home pregnancy test. Answered by Arlinda Reigner 3 months ago.

Yes, the pill is all I count on, since it is 99% effective. I'm 22, living with my bf, and we have sex day and night, so I don't worry about if I'm ovulating since again, I count on the pill. If I am pregnant, I don't even know what I'll do, since I know I don't want to have kids yet, and I don't even know for sure if I WANT to have any... I enjoy my freedom. :) You can't see the world if you're toting a baby along, which is why I've done my best to be responsible and not end up like my mom did (preggy at 15, had child at 16). Answered by Alix Pifer 3 months ago.

Sweetie, don't count on just the pill. I have 3 kids and was on birth control with all 3. Thank the Lord I was married when we got pregnant and I din't have to worry. The best advice I can give you is take the test and see that way you can make plans on how to care for yourself and the baby. You don't want to be pregnant and keep taking the pill. Hope that helps!! Good Luck and God Bless!! Answered by Mandy Maxey 3 months ago.

The only way to be sure is to go see your doctor. i dont see how Tylenol would affect the effectiveness, but im no expert in the pills. I do know that the lower the hormonal level, the higher the incidence is to get pregnant. Wait a little bit and go have a Doctor do a blood test. The blood may just be spotting which is common while on the pill. Best of luck to you. Answered by Tasha Wasinger 3 months ago.

Did you just get on this pill? Because spotting is a side effect. I got spotting for the first time at different occassions within 3 months of getting on a new pill. If this is a new pill, the fact that your breasts are tender could mean that your breasts are growing because some pills make breasts grow! I doubt it that you are pregnant, but why don't you just take a pregancy test to find out the truth? Answered by Allegra Whiting 3 months ago.

Well have you done any of those things to make it not work? As with all birth control pills you gotta be careful not to take any other pills thats might cancel out that one and think really hard...do you think you had sex when you were ovulating? that is 2 weeks after your period if so then there could be a chance because other than that you cant concieve unless you ovulate Answered by Miquel Kinghorn 3 months ago.

Cough syrup can make your birth control less effective, any kind of medicine can. basically, wait til you miss your period before worrying that you're pregnant, take a test then. also, if you've only been on the pill a couple months, your body takes time to adjust to it, so you can spot at random times in your cycle Answered by Mohammad Lomago 3 months ago.

i wouldn't get too worried about the spotting. i'm on birth control and about once a month i'll have a little pink as well. its nothing to worry about... just a side affect of birth control. the breast tenderness could also just be another side affect. expecially if you are spotting, that means that ur body has those hormones actively, so it would make sense for your breasts to be tender and have spotting at the same time. i wouldnt get too worried at this point! Answered by Thu Bar 3 months ago.

I'd say you should invest in a pregnancy test, just to be safe. If you recently switced birth control (method or brand), spotting tends to be a common side effect, but if you've been on it a while, taking a test can't hurt. Answered by Elna Mitrani 3 months ago.

Sometimres your body starts to not work correctly with the current pill, I was on one for about 8 months and started spotting, it turned out that the hormones in my body didn't like it and it was not strong enough for me. Go to you doctor she may think the same thing for you, and it could be easy enough to stop by just changing the pill you on. Answered by Maryellen Enochs 3 months ago.

While the pill is very affective it isn't full proof so you could be pregnant if you aren't using condoms as backup ... but the pill can sometime cause pregnancy symptoms. Answered by Sharan Gettig 3 months ago.


NuvaRing ?
I just started it and was reading through the drug facts and it said...If NuvaRing is taken with certain other drugs, the effects of either could be increased, decreased, or altered. It is especially important to check with your doctor before combining NuvaRing with the following: Acetaminophen (Tylenol)... Asked by Marlon Fetherston 3 months ago.

I just started it and was reading through the drug facts and it said... If NuvaRing is taken with certain other drugs, the effects of either could be increased, decreased, or altered. It is especially important to check with your doctor before combining NuvaRing with the following: Acetaminophen (Tylenol) Antibiotics such as ampicillin and tetracycline Anticonvulsants such as Dilantin, Phenobarbital, Tegretol, Trileptal, Topamax, Felbatol Antifungals such as Gris-PEG, Nizoral, Sporanox Atorvastatin (Lipitor) Clofibrate (Atromid-S) Cyclosporine (Neoral, Sandimmune) HIV drugs classified as protease inhibitors (Agenerase, Crixivan, Fortovase, Invirase, Kaletra, Norvir, Viracept) Morphine (Astramorph, Kadian, MS Contin) Phenylbutazone Prednisolone (Prelone) Rifadin (rifampin) St. John's wort Temazepam Theophylline (Theo-Dur) Vitamin C So....Tylenol and Vitamin C!....Should I ask my doctor about this? Has anyone else using asked their doctor about this Answered by Randell Wiren 3 months ago.

Vitamin C may raise levels of estrogen in the blood. You will have to take at least 1g to have that happen which is a lot. Tylenol is affected by the hormones and may lower the blood levels of acetaminophen. Neither of them lower the effectiveness of the Nuva Ring. Your doctor can verify this with you. You can read the link below that will tell you what every interaction for each drug is. It is for the pill but the drug interations are the same for the Nuva Ring. They contain the same hormones. Answered by Darnell Swetnam 3 months ago.

Nuvaring Facts Answered by Shenna Tonschock 3 months ago.

I did use it and I loved it. After the first try it's really easy to insert and remove so it quickly becomes no big deal. And you can take it out for a few hours at a time and not lose any effectiveness so I always took it out whenever my husband and I got romantic. I always had bad side affects with the high level of ingested hormones with traditional birth control pills so the ring was a great solution for me. Answered by Randy Medbery 3 months ago.


How do you raise your blood Sugar level?
What medicines bring your blood sugar levels up? Asked by Noah Yeaton 3 months ago.

Blood sugar also known as Glucose , the only safe "medicine" is sweetened water , just a few days ago a patient developed cardiac arrest while being given a Glucose increasing medication during an Glucose evaluation test anyway here is a list of medicines that can cause HYPERGLYCEMIA (High Blood Sugar) Abacavir (Ziagen®) Abacavir + lamivudine, zidovudine (Trizivir®) Acetazolamide (Diamox®) Acitretin (Soriatane®) Albuterol (Ventolin®, Proventil®) Albuterol + ipratropium (Combivent®) Ammonium chloride Amphotericin B (Amphocin®, Fungizone®) Amphotericin B lipid formulations IV (Abelcet®) Amprenavir (Agenerase®) Anidulafungin (Eraxis®) Aripiprazole (Abilify®) Arsenic trioxide (Trisenox®) Asparaginase (Elspar®) Atazanavir (Reyataz ®) Atenolol + chlorthalidone (Tenoretic®) Atorvastatin (Lipitor®) Atovaquone (Mepron®) Baclofen (Lioresal®) Benazepril + hydrochlorothiazide (Lotension®) Betamethasone topical (Alphatrex®, Betatrex®, Beta-Val®, Diprolene®, Diprolene® AF, Diprolene® Lotion, Luxiq®, Maxivate®) Betamethasone +clotrimazole (Lotrisone® topical) Betaxolol Betoptic® eyedrops, (Kerlone® oral) Bexarotene (Targretin®) Bicalutamide (Casodex®) Bisoprolol + hydrochlorothiazide (Ziac®) Bumetanide (Bumex®) Caffeine (Caffeine in moderation may actually be beneficial in diabetes but in large amounts can raise blood sugar.) Candesartan + hydrochlorothiazide (Atacand HCT®) Captopril + hydrochlorothiazide (Capozide®) Carteolol (Cartrol® oral, Occupress® eyedrops) Carvedilol (Coreg®) Chlorothiazide (Diuril®) Chlorthalidone (Chlorthalidone Tablets®, Clorpres®, Tenoretic®, Thalitone®) Choline salicylate (Numerous tradenames of aspirin formulations: check label.) Choline salicylate + magnesium salicylate (CMT®, Tricosal®, Trilisate®) Clobetasol (Clobevate®, Cormax®, Cormax® Scalp Application, Embeline® E, Olux®, Temovate®, Temovate® E, Temovate® Scalp Application) Clozapine (Clozaril®, FazaClo®) Conjugated estrogens (Estrace®, Estring®, Femring®, Premarin®, Vagifem®, Cenestin®, Enjuvia®, Estrace®, Femtrace®, Gynodiol®, Menest®, Ogen®) Conjugated estrogens + medroxyprogesterone (Premphase®, Prempro®) Corticosteroids (Numerous tradenames: check label.) Corticotropin Cortisone (Numerous tradenames: check label.) Cyclosporine (Sandimmune®, Neoral®, Gengraf®) Daclizumab (Zenapax®) Decitabine (Dacogen®) Desonide (DesOwen®, Tridesilon®) Desoximetasone (Topicort®) DO NOT TAKE ANY OF THESE MEDICATIONS WITHOUT AN PRESCRIPTION Answered by Rosana Dawsey 3 months ago.

Consume pure carbohydrates or sugar, whether it is fruit juice, honey, sucrose, etc. Blood suger level is a transient condition and is directly impacted on what you eat and how quickly your body metabolizes it. Answered by Olivia Kumro 3 months ago.

Anything you eat that has protein, carbs, or fats will raise it. Answered by Simonne Carrel 3 months ago.


What is in grapefruit that makes react with medication (cholesterol)?
my dad was told he can't have grapefruit because of his cholesterol medication he's is on Asked by Jorge Discenza 3 months ago.

Drugs affected by grapefruit juice[17] Grapefruit and grapefruit juice have the potential to interact with numerous drugs. A number of organic compounds, identified as furanocoumarin derivatives, interfere with the hepatic and intestinal enzyme cytochrome P450 isoform CYP3A4 and are therefore primarily responsible for the interaction. However, bioactive compounds in grapefruit juice may also interfere with P-glycoprotein and organic anion transporting polypeptides (OATPs) either increasing or decreasing bioavailability of a number of drugs. Pomelo (the Asian fruit which was crossed with an orange to produce grapefruit) also contains high amounts of furanocoumarin derivatives Drugs affected by grapefruit juice[17] Drug classMajor InteractionsMinor interactions Calcium channel antagonistsPlendil Cardene (Nicardipine) Procardia (Nifedipine) Nimotop Sular DynaCirc AntiarrhythmicsCordarone Multaq Statins (HMG-CoA reductase inhibitors)Mevacor (Lovastatin)Lipitor Baycol (off the market) ImmunosuppressantsSandimmune (Cyclosporine) Prograf Rapamune Mercaptopurine DissociativesDextromethorphan Sedatives, hypnotics, and anxiolyticsBusparHalcion Versed Valium (Diazepam) Sonata (Zaleplon) Alprazolam Other psychotropicsTegretol (Carbamazepine) Desyrel Serzone Seroquel Fluvoxamine AntihistaminesSeldane (off the market) Diphenhydramine (partially) Hismanal (off the market)Claritin (Loratadine) HIV protease inhibitorsInvirase Norvir Viracept Agenerase HormonesOrtho-Cept (Ethinyl estradiol) Depo-Medrol (Methylprednisolone) Other drugsViagra Propulsid[18] [edit]Drugs affected by grapefruit juice[17] Drug classMajor InteractionsMinor interactions Calcium channel antagonistsPlendil Cardene (Nicardipine) Procardia (Nifedipine) Nimotop Sular DynaCirc AntiarrhythmicsCordarone Multaq Statins (HMG-CoA reductase inhibitors)Mevacor (Lovastatin)Lipitor Baycol (off the market) ImmunosuppressantsSandimmune (Cyclosporine) Prograf Rapamune Mercaptopurine DissociativesDextromethorphan Sedatives, hypnotics, and anxiolyticsBusparHalcion Versed Valium (Diazepam) Sonata (Zaleplon) Alprazolam Other psychotropicsTegretol (Carbamazepine) Desyrel Serzone Seroquel Fluvoxamine AntihistaminesSeldane (off the market) Diphenhydramine (partially) Hismanal (off the market)Claritin (Loratadine) HIV protease inhibitorsInvirase Norvir Viracept Agenerase HormonesOrtho-Cept (Ethinyl estradiol) Depo-Medrol (Methylprednisolone) Other drugsViagra Propulsid[18] [edit] Answered by Fatima Durr 3 months ago.

Grape fruit is good for reducing cholesterol,one should not take this fruit along with cholesterol medicine,it will have lot of side effects... Answered by Luella Ancic 3 months ago.


My doc just gave me samples of loestrin 24 fe. I take lexapro, antidepressant. anyone else take this combo?
Asked by Aretha Stempert 3 months ago.

the sample is the same as the real one, the brown actualy dont contain any of the birthcontrol supplement they are iron to help during your period, also they are to help you remeber to take your pill everyday at the same time! Answered by Elisa Boerst 3 months ago.


How long does it take ortho-cyclen to be effective?
i began taking it this past friday the 3rd, my pamplet from the clinic says that on the 8th day that i take it i will be protected, but i've heard different opinions. some say a month, some say 2 weeks?? whats the real time?? thanks Asked by Syreeta Baisden 3 months ago.

Hi pihljn, yes, you may need to use back-up birth control, such as condoms or a spermicide, when you first start using this medication(7-10day). Follow your doctor's instructions. But you need know that some drugs can make Ortho Cyclen less effective, which may result in pregnancy. Tell your doctor about all the prescription and over-the-counter medications you use, including vitamins, minerals and herbal products. Do not start using a new medication without telling your doctor. -phenylbutazone (Azolid, Butazolidin); -St. John's wort; -antibiotics such as amoxicillin (Augmentin), ampicillin (Omnipen), doxycycline (Doryx, Vibramycin), griseofulvin (Grisactin, Grifulvin V, Fulvicin PG), minocycline (Minocin), penicillin (Veetids, Pen Vee K, Bicillin), rifampin (Rifadin), rifabutin (Mycobutin), tetracycline (Sumycin, Achromycin, Robitet), and others; -seizure medicines such as phenytoin (Dilantin), carbamazepine (Tegretol), felbamate (Felbatol), oxcarbazepine (Trileptal), topiramate (Topamax), or primidone (Mysoline); -a barbiturate such as amobarbital (Amytal), butabarbital (Butisol), mephobarbital (Mebaral), secobarbital (Seconal), or phenobarbital (Luminal, Solfoton); or -HIV medicines such as amprenavir (Agenerase), atazanavir (Reyataz), tipranavir (Aptivus), indinavir (Crixivan), saquinavir (Invirase), lopinavir/ritonavir (Kaletra), fosamprenavir (Lexiva), ritonavir (Norvir), or nelfinavir (Viracept). There may be other drugs not listed that can affect Ortho Cyclen. Also you need stop using this medication and call your doctor at once if you have any of these serious side effects: - sudden numbness or weakness, especially on one side of the body; -sudden headache, confusion, pain behind the eyes, problems with vision, speech, or balance; -chest pain or heavy feeling, pain spreading to the arm or shoulder, nausea, sweating, general ill feeling; - a change in the pattern or severity of migraine headaches; -nausea, stomach pain, low fever, loss of appetite, dark urine, -swelling in your hands, ankles, or feet; or -symptoms of depression (sleep problems, weakness, mood changes). Jason Homan Answered by Erminia Larrow 3 months ago.

You do not ought to begin at the first Sunday. When my placebo capsules are long past then I begin my BC capsules once more. If you're simply establishing the capsules then you definitely will have to wait 7 days (it additionally will have to say this within the recommendations) earlier than you have got unprotected intercourse. If you will have been on them for a even as now then you're well to head. The capsule, while taken competently, is ninety nine% amazing. Answered by Aurea Fuerstenberg 3 months ago.


Forms

ApplId/ProductId Drug name Active ingredient Form Strenght
021007/001 AGENERASE AMPRENAVIR CAPSULE/ORAL 50MG
021007/002 AGENERASE AMPRENAVIR CAPSULE/ORAL 150MG
021039/001 AGENERASE AMPRENAVIR SOLUTION/ORAL 15MG per ML **Federal Register determination that product was not discontinued or withdrawn for safety or efficacy reasons**

Similar Active Ingredient

ApplId/ProductId Drug name Active ingredient Form Strenght
021007/001 AGENERASE AMPRENAVIR CAPSULE/ORAL 50MG
021007/002 AGENERASE AMPRENAVIR CAPSULE/ORAL 150MG
021039/001 AGENERASE AMPRENAVIR SOLUTION/ORAL 15MG per ML **Federal Register determination that product was not discontinued or withdrawn for safety or efficacy reasons**

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