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Promethazine hydrochloride is an antihistamic medication that relieves the allergy related symptoms including sneezing, runny nose, coughand itchy of the nasal/oral mucosa. Codeine is a narcotic drug with moderate antitussive (cough suppressant) properties and should be avoided in childrens (<6 years) due to mild respiratory depressant effect as with other narcotics. Never drink alcohol while taking a Narcotic. Its not recommended to take for it for a longer period or in a higher dose than prescribed and reduce your dose gradually to avoid withdrawal reactions. You should not use this medication if you have active asthma, COPD or if you are taking Sedatives, narcotics, or antidepresants. If you experience severe drowsiness (sedation) you should go to the hospital.
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can i get high off promethazine hydrochloride 25 mg?
can i get high off promethazine hydrochloride 25 mg? pill white and round with GG 225
wooop, there it is!
  Sure, just take 19 of them, they'll make you pickle!
side effects of promethazine hydrochloride pills?
my insomnia has worsened lately so my doctor gave me some promethazine hydrochloride 25mg pills. I'm 14 years old and I just wanted to ask whether anyone of you had taken these pills before and whether you can tell me some of its side effects.
  I find some information about Promethazine at
There is description of side effects, dosage, using of this medicine. Hope it will be useful.
promethazine hydrochloride what is it used for?
  It's brand name is Phenergan. Phenergan is an antihistamine that relieves nasal stuffiness and inflammation and red, inflamed eyes caused by hay fever and other allergies. It is also used to treat itching, swelling, and redness from hives and other rashes; allergic reactions to blood transfusions; and, with other medications, anaphylactic shock (severe allergic reaction).Phenergan is also used as a sedative and sleep aid for both children and adults, and is prescribed to prevent and control nausea and vomiting before and after surgery and to prevent and treat motion sickness. It is also used, with other medications, for pain after surgery.
Have you ever heard of someone abusing the drug Promethazine? I was wondering if it has side effects, as I think someone might have jacked my prescription. I got it for a surgery to help with nausea, and I was wondering why anybody would have a reason for stealing PROMETHAZINE?
  One reason would be for the anti nausea it gives so if you were hungover. Promethazine is sometimes used as a recreational drug in conjunction with codeine in prescription cough syrup. The syrup by itself contains 7% alcohol. The mixture of Sprite and cough syrup with codeine, which is known as "purple drank" or "Sizzurp", is popularized in the rap world, especially in the Houston area.
What is the difference between promethazine with codein and promethazine with dextromorphan?
Will it kill me? We have the promethazine with dextromorphan will this still work for purple lean?
Bob B
  Dextromethorphan is a cough suppressant that is found in many over-the-counter cough medicines. Codine is a narcotic that is used as cough suppressant, pain reliever, and a hypnotic.

Promethazine is used mostly to prevent nausea. It is also used as part of preoperative sedation to prevent nausea from the other types of sedation used.

If you have both, I don't recommend using them BOTH at the same time. You may overdose.
What is the difference between Promethazine VC w/ Codeine and Promethazine w/ Codeine?
I get pneumonia frequently and they usually give me Promethazine w/ Codeine 10-6.25 for my cough. This time they prescribed Promethazine VC w/ Codeine 10-5-6.25 instead. What is the difference and what does the "VC" mean?
Fireman 1
  VC stands for the addition of a decongestant- so you have promethazine which is an antihistamine and codeine an opiod all in one. Sounds like it may work for you. Be careful with driving until you get used to their effect. It may also affect your sleep patterns.
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I hurt my hand and I was wondering if it would still be safe to take a 2 year outdated meprozine?
we have an old bottle laying around it has promethazine and hydrochloride in it
keep it movin
  O_O if you wanna die sure!
Teehee! ♥
Promethazine & Solodyn (Stomach Ache)?
My stomach has been hurting for the past hour or so feeling as if I may be vomit at some point later. I'm 16 and I take a pill of Solodyn and Claritin every night for Acne and Allergies. (Solodyn is prescribed) I had also taken a Loperamide Hydrochloride for constipation and diarrhea symptoms at about 12:30am EST (The other 2 pills at about 10pm EST. If I use a Promethazine (prescribed for stomach aches after my nasal septum surgery) suppository for this stomach ache now will it affect me negatively with having taken the other meds?
Any questions ill edit the post and answer my best. Thanks for any help in advance.
Steve G

Only use the promethazine if you are nauseated or vomiting. It won't do a thing for a stomachache.
John M
The Pharmacist suggested if I did not feel comfy with his theory. Just thought I would ask others!
Do they make on for vaganial insert. Just want to know before I talk to my DR again.
hippo 1
  you didn't say for what purpose. As an antiallergic, as a sedative...If they are suppositories, they are meant for rectal use. On the other way i know that promethazine can be used as un spermicide. And it's a problem, suppositories may not release the active drug at the vaginal level because they are formulated for the rectal mucosa.
will Promethazine hydrochloride get u high?
my friend found some in his brothers room an he is trying to find out if it will get him "high"
its 25 mg
  It's an anti-allergy medication. Ask yourself if taking benadryl or claritin gets you high, and you'll have your answer.
Dr. House
What can I tell my doctor to get Promethazine prescription?
I get it illegally but I'm getting too nervous about it, just help a brother out. I'm thinking that if I tell him that I get motion sickness when driving and that someone reccomended Promethazine it should work.
  You can get it over the counter in the United Kingdom, Switzerland, and many other countries (brand names Phenergan, Promethegan, Romergan, Fargan, Farganesse, Prothiazine, Avomine, Atosil, RhinathioL) So I would try to order it from one of the companies over there in bulk.

It's also used as an antihistamine (like Bennedryl). It blocks the effects of histamine in your body.

Promethazine treats allergy symptoms such as itching, runny nose, sneezing, itchy or watery eyes, hives, and itchy skin rashes. It also prevents motion sickness, and treats nausea and vomiting or pain after surgery and is used as a sedative or sleep aid. (Taken off the pamphlet that comes with a prescription)

So I would go with really bad allergies that keep you awake all night.

PS they wont give you a prescription if you have high blood pressure.

purple drank <3 haha
Whats the difference between Promethazine w/codeine and Promethazine DM? What does DM mean?
  One has codeine and the other has dextromethrophen in it. They are both cough suppressents.
Roberta P
Help sleeping tablets?
I used to take Zopiclone 7.5mg sleeping tablets.

I've recently been change to Promethazine Hydrochloride 25mg.

Has anyone else been on this as, i don't feel it helps at all.

The doctor said it was a sleeping tablet but is it? help please

  Hi Doctors seem to be trying not to give out full on sleeping tablets these days so are giving people antihistamines instead. They are not as strong as sleeping tablets and I would think you need to be telling your doctor that they are not working.

Promethazine is derived from a group of medicines called phenothiazines, however, it is also part of the family of sedating antihistamines. Histamine is a chemical in the body that causes the symptoms of an allergic reaction. These can include inflammation of the skin, airways or tissues, rashes, itching of the skin, eyes or nose, nasal congestion and narrowing of the airways. Promethazine blocks the binding of histamine to receptors in many areas of the body and thereby prevents the actions of histamine. This helps prevent and relieve the typical symptoms of an allergic reaction. Histamine may be released from and act in a small (localised) area of the body e.g the nose. Alternatively, histamine can result in a serious or complete body reaction e.g. anaphylactic reaction. Promethazine is useful for the prevention or relief of localised or less serious allergies such as hay fever or itchy rash in addition to serious allergic reactions such as anaphylaxis. Promethazine blocks histamine receptors in an area of the brain called the vomiting centre. It also acts to block other receptors in the vomiting centre (serotonin receptors). Therefore promethazine prevents the vomiting centre from sending the nerve messages to the stomach that would normally result in vomiting. Promethazine also acts on receptors in the gut (muscarinic receptors) to decrease the amount of fluid secreted from the lining of the gut and decrease the actions of the gut muscles. This further aids the treatment or prevention of nausea and vomiting. Promethazine is known as a sedating antihistamine as it enters the brain in significant quantities and causes drowsiness. As a result it is commonly used for the short-term treatment of sleep disturbances and to provide sedation prior to minor procedures or surgery.

What is it used for?
Allergic conditions such as hay fever and itchy rash
Difficulty in sleeping
Life threatening allergic reaction (anaphylactic reaction)
Nausea and vomiting
Sedation prior to surgery (preoperative sedation)
Does Promethazine or Codeine have any traces of cocaine in it?
Some dumbass white dude at my skool keeps trying to say Purple Drank/Purple Lean has cocaine in it. I'm tellin him that all Purple Drank is Sprite, and Promethazine/Codeine Cough Syrup. So basically the question is: does Promethazine or Codeine have any cocaine? I know Codeine is a narcotic, made from opium, so I dont think it has any cocaine in it.
  No. Cocaine is stimulant, and a completely different compound extracted from coca leaves. Codeine is an opiate, synthesized from morphine which in turn is synthesized from opium. Cocaine would definitely not be in a codeine mixture.
Does all promethazine have codine in it my bottle just says promethazine dm?
I have a bottle of promethazine dm but it doesent say if it contains codine or not
if not than what can i do to it to get high?
  No narcotics.

Be realistic. No medical professional is going to help you do something dumb like abuse Rx drugs.
I was about to take come promethazine but it says it expired about 5 1/2 months ago.....So my question is is it safe to take it even though it expired?

Wouldnt it just make potency less?
Dj R
  Don't take medicine past the expiration.

In some cases old meds become less potent but some can become more potent - which can easily lead to an overdose.
Is it okay to mix Promethazine and Profen II DM?
I take Promethazine for stomach aches and i have been having tough issues with my coughing, so is it okay to mix the two? also Ive heard a lot about cough medicine abuse, are the two going to mess me up?

I took adderall xr 30mg this morning but im sure it wont affect the medicine, will it?
Zach F
Question for someone whos been prescribed promethazine with codeine syrp recently?
I was always curious about promethazine with codeine syrup and i wanted to know what dosage it says on the bottle... Does it just say how to take it or the name, or does it show dosage wise! Just wonderin, thanks!
  the dosage is usually determined by a doc, & depending on his/her directions, it will say how to take it. It really works to get rid of a bad/resistant cough & a good night's sleep.
Is it safe to use promethazine with an epipen?
I had my wisdom teeth removed on Friday and was prescribed promethazine for nausea. Today, after taking that, my dust allergy acted up and I took benadryl along with my epipen. Is this safe? I didn't see any warnings on either medication. Thanks for any help.
nyx コト
  It should be fine.

Why did you use the epipen? That's for life threatening allergic reactions. I've never seen a dust allergy that was life threatening.
with a really bad cough is there somewhere i can get promethazine with codeine w/o prescription?
where can i find promethazine w codeine plz help me out
  not without a prescription
What would the combination of Promethazine and Ambien do, if taken in fairly large amounds and same time?
I'm just curious what would ambien and promethazine do if taken at the same time?
Curious Cutie
  That sounds like a poor man's "Purple Drank". Using a sleeping pill instead of codeine in the drug you're trying to emulate will drastically increase the risk of respiratory failure. The original is dangerous enough. What you just mentioned is even worse. If you go too far over the recommended medicinal dose you run a very high risk of passing out and your lungs shutting down.

The increased risk comes from the fact that both Promethazine and Ambien can stop your breathing at high doses. You'd be taking two drugs that, individually, could kill at a high dose.

All these drugs show up on a standard toxicology screen.
Lean, Promethazine, Codeine, Sizzurp... Heeelp?
What are the effects of Promethazine/codeine? Is there any bad side effects or any bad reactions you can get from it? I've had a bad past with weed, & have major panick attacks that last a while whenever i do smoke. So i completely quit. Alcohol doesnt have any bad effects on me. But i wanna try leaning, Anybody have any bad experiences ? Do you think i'll panic from it ?
Would taking Paxil, Morphine, and promethazine with codeine all at the same time kill?
I need to know right away, if there deadly or not. I just took all three together:
120mg of Morphine
About 5 Table Spoons of Promethazine w/Codeine
& 40mg of Paxil
Possible overdose on Promethazine and Codeine cough syrup?
I got confused and took 2 Tablespoons of Promethazine with Codeine cough syrup instead of 2 teaspoons do i need to call poison control or will i be okay?
  You'll be fine. You might feel a little high though. Just lay down, drink lots of water.
Sex Addict
can you take Meloxicam with Promethazine w/ Codeine?
i was at the doctors Wednesday with just a sore throat. nothing major. so i got prescribed Meloxicam to reduce the swelling. The day after worse symptoms started kicking in. Just went back to the doctors today and he prescribed me the Z-pack and Promethazine w/ Codeine. I forgot to ask if i could take the Meloxicam with that, so can i?
Tyler Bryant
How many promethazine should I take with one oxycodone?
I just got my wisdom teeth pulled out and my docter perscribed me oxycodone to relieve the pain and promethazine to relieve any sickness I would feel from the pain reliver. I am scared to take the the oxycodone cause im scared of being nauses!
Caleb Mcneal
  Oxycodone for a pulled wisdom tooth? I hope you don't get addicted to it. If a doctor prescribed the medicines for you, then the prescribed directions for both drugs should be listed on the bottles.
Could this drug I'm taking be causing my depression?
I've got depression. I haven't been diagnosed, nor do I want to tell my mum about it. It's all come out of what's happened since my start at school through to grade 11, and I'm a male, 15 years old. But I think this drug that I'm taking might be worsening it.

It's not anything big. It's just a simple antihistamine. It's called Phenergan, and the tablets are 10mg each. It's "scientific name", I guess, is Promethazine Hydrochloride. It says that the only side effect is drowsiness, which has affected me, and it supposedly contains lactose, which I'm not intolerant to.

Is this Phenergan actually making my depression worse or is the depression just all from my life experiences?
Nineteen-Twenty by Ten-Eighty Pixels :)
  Why are you taking so much Phenergan? It is typically used as an antiemetic (reducing nausea) and has been almost completely replaced as a drug to treat allergies. Although sometimes it is used for an acute allergy. No matter what I highly recommend you look into another medication.

Can it be making you worse? Yes. Is it actually making you worse? It is almost impossible to say. It may also be a combination of factors.

Phenergan is also, as the other person said, a bit more complex. Actually many of the best antiemetics are better known as antipsychotics like haloperidol. Antipsychotics are also antihistamines, actually the first antipsychotic was developed to treat allergies and it was tested on psychiatric patients and many got better. Phenergan falls within this group of drugs that are antihistamines but have many other actions that control psychosis. Phenergan is not used to treat psychosis because it is very weak and not very effective but it still retains those antiemetic properties.

My point is that despite the fact Phenergan is weak and you are on a tiny dose it still does impact some of those neurotransmitters in your brain like dopamine.

See your doctor, try a new medication and see what happens. If you feel better then it was the Phenergan. Also no drug on Earth has one side effect, although drowsiness is most common it has other side effects.

Lastly I don't know exactly why you have not told your mum about your depression but you should. Depression is not weakness or failure, and if it has gone beyond the mild depression everyone has from time to time then you need to get help.
Tramadol, Flexeril and Promethazine the risk of seizure can I take?
I've taken 3 tramadol earlier today last one around 6pm. It made my stomach hurt so I took a promethazine around 10pm. Now, the pain is back and I want to sleep is it safe to take my flexeril? I don't have a history of seizures but when I check the interaction it says theres a risk for seizures. My pharmacist says that's only if you've had history of seizures who do I believe?
Count Drakul
  i take Tramadol daily and I have taken Promethazine with it. It may increase the effects of tramadol and the drug interactions site does say it may cause seizures but i think that is very rare. You usually have to have a history of seizures for this to happen usually. It is also associated with large doses of Tramadol, 300mg and up. The Flexeril should be fine too. 9 times out of 10 the pharmacy wont tell you to do anything dangerous but sometimes the drug interaction checker will scare you. It's always good to be cautious though, you don't want to be another Heath Ledger.
Deep Thinker
what is the difference between promethazine vc syrup and promethazine dm syrup?
Maria P
  promethazine vc does NOT contain codeine unless its says promethazine vc with codeine.

prom-vc is an antihistamine and decongestant

prom-dm is is an antihistamine and cough suppressant
How much Promethazine is "safe" to take if you weigh 110 pounds?
I weigh 110 pounds and need to take Promethazine because of allergies. How much is safe and how much does it take to overdose?
  To be perfectly blunt, it's however much your doctor prescribes to you. Any prescription will be given based on your need which can involve factors more than just weight, age, and gender and some drugs require blood work to find the appropriate dosage. Online, we would have no access to the basic information that would be required to say what dosage you would need... but moreso, only your doctor can prescribe your needed dose so whatever dose anyone here might say is moot if your doctor won't prescribe that dose for you. points out that it's simply an antihistamine (which also can help with motion sickness)... it's not really a drug you can abuse so the highest "safe" dose would also be a moot point. The answer would be to ask your doctor how much you should be taking. Good luck and I hope I helped!

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